the effects of rope training on lymphocyte abca1 expression, plasma apoa-i and hdl-c in boy adolescents

conclusions the findings of this study proved that eight-week interval endurance rope training can have positive effects on lymphocyte abca1 protein expression (as gatekeeper of reverse cholesterol process) and lipid profiles among overweight and obese boy adolescents. objective the current study aimed to investigate abca1 expression in lymphocytes, plasma apolipoprotein a-i and hdl-c in response to eight-week interval endurance rope training in overweight and obese boy adolescents. patients and methods thirty students (17.3 ± 1.1yr, 85.73 ± 11.68 kg and 28.41 ± 2.36 kg / m²) volunteered and were randomly assigned into training (n = 15) and control (n = 15) groups. exercise protocol was interval endurance rope training (8 wk, 4 d/wk and 40 min/d). cell hemolysis and sensitive elisa method was used for lymphocyte abac1 protein expression.t-test was employed. results the independent-samples t-test results showed that after 8 weeks iert, the levels of lymphocyte abca1 expression(p = 0/001) and vo2max(p = 0/001) significantly increased and plasma levels of tg(p = 0.017), tc(p = 0.001), ldl-c/hdl-c(p = 0.026),tc/hdl-c(p = 0.002) and measures of bf%(p = 0/015)and bmi(p = 0.042) as anthropometric indicators significantly decreased. changes of other variables such as increase in apoa-i, hdl-c and decrease in ldl-c, body weight, were not significant. background early obesity and its transfer to the adulthood, increases likelihood incidence of coronary artery disease (cad). atp-binding cassette transporter (abca1) as a member of the abc transporters family plays a crucial role in reverse cholesterol transport and cad prevention.